This had led to Tasmanian devils being listed as endangered by the International Union for Conservation of Nature (IUCN). Since its emergence around 1996, the disease has spread rapidly across the state resulting in a population decline of around 80 %. The devil facial tumour disease (DFTD) is currently threatening Tasmanian devils with extinction. The Tasmanian devil ( Sarcophilus harrisii) is the world’s largest surviving marsupial carnivore. This understanding will allow for the development of devil specific assays and reagents and allow for future studies into the immune response of the Tasmanian devil immune system to DFTD. Conclusionsīy using multiple data sources as well as targeted search methods, highly divergent genes across the Tasmanian devil immune system were identified and characterised. The repertoire of genes in these families was similar to the opossum, however devil specific duplications were seen and orthologs to eutherian genes not previously identified in any marsupial were also identified. ![]() Constant regions for immunoglobulins and T cell receptors were also identified. We identify and describe 119 cytokines including 40 interleukins, 39 chemokines, 8 interferons, 18 tumour necrosis family cytokines and 14 additional cytokines. We focus on immunoglobulins, T cell receptors and cytokine families. In this study we characterise immune gene families of the Tasmanian devil. This has provided us with the raw data required to begin to investigate the Tasmanian devil immunome in depth. In 20 two genome sequencing projects of the Tasmania devil were released. In order to prevent the spread of this disease a thorough understanding of the Tasmanian devil immune system and its response to the disease is required. ![]() ![]() The Tasmanian devil ( Sarcophilus harrisii) is being threatened with extinction in the wild by a disease known as devil facial tumour disease (DFTD).
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